We are happy to announce the publication in Pharmaceutics of the first paper related to our hydrogel based on Olea europaea leaf extract (OELE) indicated for the healing of wounds of full and partial thickness.
The publication is based on a study that has been designed and carried out by several authors who come from different areas of basic research and therapeutic management of skin lesions of any depth.
It is known that the excess of free radicals in the wound environment contributes to its quiescence during the inflammatory phase, favouring hard-to-heal wounds. Oxidative stress negatively affects cells and the extracellular matrix, hindering the healing process. In this study, the significant antioxidant activity of Olea europaea leaf extract was observed and assessed in different in vitro assays and produced an early and sustained wound-healing stimulating effect superior to controls in diabetic mice.
The authors conclude that “this novel amorphous hydrogel presents an important reactive oxygen species (ROS) scavenger capacity due to the high phenolic content of OELE, which protects skin cells from oxidative stress and contributes to the physiological process of wound healing” thus underlining the innovativeness of the antioxidant approach whenever facing skin lesions of any depth.
Casado-Diaz A et al. Evaluation of Antioxidant and Wound-Healing Properties of EHO-85, a Novel Multifunctional Amorphous Hydrogel Containing Olea europaea Leaf Extract. Pharmaceutics 2022, 14, 349. https://doi.org/10.3390/pharmaceutics14020349
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